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Insulin Responses to Glucose and Secretin in Uraemic and Normal Subjects
Author(s) -
Isaac R.,
Nivez M. P.,
Ardaillou R.,
Meyrier A.
Publication year - 1972
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1972.tb00680.x
Subject(s) - medicine , endocrinology , insulin , basal (medicine) , secretin , secretion
. Insulin secretion was studied in two groups of subjects: controls and uraemic patients on maintenance haemodialysis. Two procedures were used: 1) four rapid glucose injections before, during and after an infusion of glucose 2) five injections of secretin at varying time intervals. The system of two functional insulin pools, as first described in normal man by Porte and Bagdade [1] is also observed in uraemic subjects. Basal insulin level is increased and glucose tolerance impaired in this group. Insulin secretion from the two pools is higher when insulin plasma levels are expressed as absolute values but becomes lower when relative values calculated as per cent of the base line are considered. Thus uraemia may be considered as associating insulin antagonism and resistance to relatively defective insulin secretion.