Premium
Hypo‐β‐Lipoproteinaemia Associated with Auto‐Antibodies Against β‐Lipoproteins
Author(s) -
Noseda Giorgio,
Riesen Walter,
Schlumpf Eva,
Morell Andreas
Publication year - 1972
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1972.tb00660.x
Subject(s) - polyclonal antibodies , antibody , chemistry , moiety , gammopathy , homologous chromosome , lipoprotein , biochemistry , medicine , endocrinology , immunology , cholesterol , stereochemistry , monoclonal , monoclonal antibody , gene
In a 19 year old patient, presenting a severe hypo‐β‐lipoproteinaemia and a polyclonal IgG gammopathy, all known causes of hypo‐β‐lipoproteinaemia could be excluded. The patient's IgG reacted with homologous and autologous low density lipoproteins like an antibody, the binding activity being localized in the Fab fragment of the IgG molecule. The reactive part of LDL appeared to be the protein moiety (apoprotein LDL). Turnover studies with radioiodinated LDL showed that the reduction of the LDL concentration in the patient's serum was due to a decreased synthesis of LDL and also possibly to an immunelimination of LDL.