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Metabolic Activity in Human Skeletal Muscle Effect of Peripheral Arterial Insufficiency
Author(s) -
Holm J.,
Björntorp P.,
Scherstén T.
Publication year - 1972
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1972.tb00657.x
Subject(s) - intermittent claudication , skeletal muscle , medicine , endocrinology , glycogen , gastrocnemius muscle , peripheral , claudication , glucose uptake , chemistry , cardiology , arterial disease , vascular disease , insulin
Succinic oxidase activity and the incorporation rates of glucose‐carbon into glycogen, lipids, lactate and carbon‐dioxide were studied in vitro in samples of skeletal muscle taken from patients with peripheral arterial insufficiency. In the patients with intermittent claudication significantly increased succinic oxidase activity and incorporation rates of glucose‐carbon were found in muscle tissue taken from the medial head of the gastrocnemius muscle. In patients with evidence of ischaemia at rest the metabolic activity in the muscle tissue was similar to the controls but significantly lower than in the patients with claudication on all points.