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Plasma Lipids and Steroid Hormones in Patients with Hypercholesterolaemia or Hyperlipaemia during Dehydroepiandrosterone Sulphate Administration *
Author(s) -
Adlebcreutz H.,
Kerstell J.,
Schaumann K.O.,
Svanborg A.,
Vihko R.
Publication year - 1972
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1972.tb00575.x
Subject(s) - dehydroepiandrosterone , estrone , endocrinology , medicine , excretion , steroid , estrogen , chemistry , hormone , cholesterol , urine , etiocholanolone , urinary system , androgen
. DHEA sulphate was administered orally in doses of 20 to 80 mg to 13 subjects with hypercholesterolaemia or hyperlipaemia. Plasma lipid and neutral steroid sulphate levels as well as the excretion of individual ll‐deoxy‐17‐ketosteroids and estrogens in urine were investigated before and during the treatment. No effect was observed on plasma free or esterified cholesterol, on total or individual phospholipid values, or on routine blood haematological or chemical analyses. However, the plasma C 19 steroid sulphate levels increased considerably as well as the urinary excretion of the 11‐deoxy‐17‐keto‐steroids, indicating good absorption of the compound administered. No significant changes in estrogen excretion following DHEA sulphate treatment could be noted. —When 13 male subjects with hypercholesterolaemia and hyperlipaemia were compared with 42 normal controls of the same mean age, a significantly lower urinary excretion of dehydroepiandrosterone and estrone as well as of estrone + estradiol was observed in the pathological series.