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Comparative Absorption of Ferri‐Haemoglobin‐ 59 Fe/Ferro‐Haemoglobin‐ 59 Fe and 59 Fe 3+ / 59 Fe 2+ in Humans with Normal and Depleted Iron Stores*
Author(s) -
Heinrich H. C.,
Gabbe E. E.,
Kugler G.
Publication year - 1971
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1971.tb00638.x
Subject(s) - ferrous , chemistry , absorption (acoustics) , valence (chemistry) , mössbauer spectroscopy , radiochemistry , mössbauer effect , inorganic chemistry , analytical chemistry (journal) , nuclear chemistry , crystallography , materials science , chromatography , organic chemistry , composite material
. The intestinal 59 Fe absorption from ferri‐ and ferro‐haemogIobin‐ 59 Fe and 59 Fe 3+ and 59 Fe + was calculated from whole body‐ 59 Fe‐retention measurements in subjects with normal and depleted iron stores. A ferri‐haemoglobin‐ 59 Fe/ferro‐haemoglobin‐ 59 Fe absorption ratio of 1.03 ±0.11 was observed for the absorption of ferri‐haemoglobin‐ 59 Fe (8.6± 0.77%) and ferro‐haemogIobin‐ 59 Fe (8.7±0.94%) in persons with normal iron stores. Depletion of iron stores caused a slight but significant higher rise of ferri‐haemoglobin‐ 59 Fe absorption (22 ± 1.7%) than the increase of ferro‐haemoglobin‐ 59 Fe absorption (18 ±0.9%) so that the absorption ratio was 1.24±0.073.—This remarkable iron valence independence of haemoglobin iron absorption is in considerable contrast to the well‐established valence dependence of inorganic iron absorption which favours ferrous iron absorption especially with rising iron doses. The 59 Fe 3+ / 59 Fe 2+ absorption ratio for a diagnostic 0.56 mg Fe dose increased from 0.43 in subjects with normal iron stores to 0.74 in persons with depleted iron stores, whereas this absorption ratio was augmented only from 0.21 to 0.28 for the therapeutic 50 mg Fe‐dose.—The different influence of iron valence on iron absorption from inorganic and haemoglobin iron supports other evidence for the existence of two separate mechanisms for ferrous iron and haem iron absorption in humans.