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Factor VIII and IX Variants. Relationship between Haemophilia B M and Haemophilia B+
Author(s) -
Meyer Dominique,
Larrieu Marie José
Publication year - 1971
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1971.tb00553.x
Subject(s) - haemophilia b , factor ix , haemophilia , haemophilia a , coagulation , medicine , antigen , immunology , genetics , biology , pediatrics
. Haemophilia A and B can be divided into at least two groups which are different from the moderate and severe forms already known. Most patients have a true deficiency, lacking both coagulant and antigenic activities, while 10% of them display a reduced coagulant activity with antigenic determinants in common with normal factor VIII or IX. These factor VIII or IX variants are genetically determined but speculation about the exact mode of inheritance would be premature. The relationship between the factor IX variant and haemophilia B M (characterized by an abnormal reaction of plasma with ox‐brain thromboplastin in a few patients with haemophilia B) is emphasized.