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Alcohol‐Drugs Interaction in Man: Alcohol and Tolbutamide *
Author(s) -
Carulli N.,
Manenti F.,
Gallo M.,
Salvioli G. F.
Publication year - 1971
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1971.tb00552.x
Subject(s) - tolbutamide , ethanol , microsome , chemistry , alcohol , pharmacology , metabolism , phenobarbital , drug metabolism , drug interaction , ethanol metabolism , diazepam , hexobarbital , drug , endocrinology , medicine , biochemistry , diabetes mellitus , in vitro
. In man tolbutamide was shown to share certain properties with the drugs handled by the hepatic drug‐metabolizing system: its prolonged administration is capable of accelerating its own metabolism; the same effect is obtained by pretreatment with microsomal inducers such as phenobarbital, diphenylhydantoin and diazepam. — Chronic addiction to alcohol produces an enhanced rate of tolbutamide metabolism; on the other hand, prolonged treatment with tolbutamide is able to increase the rate of ethanol oxidation. The existence of a microsomal oxidation of ethanol supports the hypothesis that microsomes may be the site of the interference between alcohol and tolbutamide. — Additional evidence is provided by the observed inhibition of tolbutamide metabolism by ethanol infusion.