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The Rate of Formation and Disappearance of Microaneurysms in Diabetic Retinopathy *
Author(s) -
Kohner E. M.,
Dollery C. T.
Publication year - 1970
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1970.tb00613.x
Subject(s) - retinopathy , diabetic retinopathy , medicine , ophthalmology , population , diabetes mellitus , endocrinology , environmental health
A method is described for the quantitative study of the life cycle of microaneurysms in diabetic retinopathy. This method was applied to a series of 21 patients, 9 with mild and 12 with severe retinopathy, 6 of whom had pituitary ablation. — The study showed a variable survival of microaneurysms; overall disappearance rates were 3.3%/month in mild and 3.2 %/month in severe retinopathy. The disappearance rate was almost always higher in the early months of the study (11.6% and 9.3 % per month) than later (0.8 % and 1 %/month) indicating more than one population of microaneurysms. — There was no significant difference in the formation and disappearance of microaneurysms between patients with mild and severe retinopathy. — Some microaneurysms showed intermittent perfusion. — Following pituitary ablation the disappearance rate of microaneurysms increased, while the formation rate of new ones decreased significantly.