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Comparison of the Absorption of a Polar Lipid, Oleic Acid, and a Non‐Polar Lipid, α‐Tocopherol from Mixed Micellar Solutions and Emulsions
Author(s) -
MacMahon M. T.,
Thompson G. R.
Publication year - 1970
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1970.tb00612.x
Subject(s) - oleic acid , chemistry , tocopherol , absorption (acoustics) , emulsion , chromatography , phospholipid , biochemistry , vitamin e , antioxidant , materials science , membrane , composite material
This study contrasts the absorption from mixed micellar solutions and from emulsions of the polar lipid, oleic acid, and the non‐polar lipid, α‐tocopherol. Rats with cannulated mesenteric lymphatics and bile ducts were infused intra‐duodenally with 14 C‐oleic acid and 3 H‐α‐tocopherol, and absorption of radioactivity into lymph was measured during the subsequent 24 hours. The results showed that oleic acid was absorbed nearly as well from an emulsion as from a mixed micellar solution, in contrast to α‐tocopherol, which was absorbed poorly from the emulsion. Further studies in bile fistula rats killed at one and three hours after the intraduodena infusions showed that the poor absorption of α‐tocopherol from an emulsion was associated with a decreased uptake into the intestinal mucosa. These findings suggest that micelle formation is more important for the absorption of non‐polar lipids, such as α‐tocopherol, than for the absorption of polar lipids, such as oleic acid.