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Study of the Permeability of the Isolated Dog Mesentery *
Author(s) -
Nagel Wolfram,
Kuschinsky Wolfgang
Publication year - 1970
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1970.tb00610.x
Subject(s) - permeability (electromagnetism) , hydraulic conductivity , chemistry , capillary action , membrane , vascular permeability , mesentery , diffusion , aqueous solution , biophysics , chromatography , materials science , thermodynamics , anatomy , composite material , biochemistry , organic chemistry , biology , endocrinology , physics , ecology , soil water
Permeability coefficients for water‐soluble substances of different molecular weights and hydraulic conductivities were measured using the isolated mesentery of the dog. The permeability coefficients of all investigated substances show the same relation to each other as the diffusion coefficients in free solution. From these data we conclude that these substances pass the mesentery by free diffusion in aqueous channels. The fraction of the endothelial membrane area which is free for diffusion was calculated to be 4%. No steric hindrance was observed even for the largest molecule (dextran mol. wt. 5). From the hydraulic conductivity and the diffusion permeability for water a mean equivalent pore radius of 0.575 μ was calculated for the endothelial cells. We conclude that the limiting membrane for peritoneal dialysis is the capillary endothelium.