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Prognostic factors for renal cell carcinoma: Trakya University experience from Turkey
Author(s) -
YURUTCALOGLU V.,
CALOGLU M.,
KAPLAN M.,
OZPUYAN F.,
KARAGOL H.,
IBIS K.,
COSARALAS R.,
KOCAK Z.,
INCI O.
Publication year - 2010
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/j.1365-2354.2009.01107.x
Subject(s) - medicine , renal cell carcinoma , perineural invasion , multivariate analysis , lymphovascular invasion , univariate analysis , oncology , stage (stratigraphy) , performance status , lymphatic system , t stage , overall survival , gastroenterology , metastasis , cancer , pathology , paleontology , biology
YURUT‐CALOGLU V., CALOGLU M., KAPLAN M., OZ‐PUYAN F., KARAGOL H., IBIS K., COSAR‐ALAS R, KOCAK Z. & INCI O. (2010) European Journal of Cancer Care 19 , 656–663 Prognostic factors for renal cell carcinoma: Trakya University experience from Turkey The purpose of the present study is to evaluate the prognostic factors of patients with renal cell carcinoma. The treatment results such as distant metastasis‐free survival and overall survival of 59 previously untreated patients were retrospectively analysed. Median follow‐up was 17.5 months (3.8–88.5 months). Overall survival was 22.4 months (3–87 months). Distant metastasis developed in 35 (59%) patients. The Eastern Cooperative Oncology Group (ECOG) performance status ( P = 0.022), tumour size ( P = 0.025) and lymphatic invasion ( P < 0.0001) were significantly effective prognostic factors for distant metastasis‐free survival on multivariate analysis. Related to overall survival, gender ( P = 0.025), ECOG performance status ( P = 0.027), nuclear grade ( P = 0.002), tumour size ( P = 0.029), T stage ( P = 0.044), nodal involvement ( P = 0.003), surgical margin ( P = 0.046), renal sinus invasion ( P < 0.0001), perineural growth ( P = 0.001) and lymphatic invasion ( P < 0.0001) were significant prognostic factors on univariate analysis. Gender ( P = 0.008), ECOG performance status ( P = 0.027), tumour size ( P = 0.025) and lymphatic invasion ( P < 0.0001) retained their significance on multivariate analysis. We concluded that the most important prognostic factors for patients with renal cell carcinomas are ECOG performance status, tumour size and lymphatic invasion.