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Cancer‐related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature
Author(s) -
DAMSTRA R.J.,
JAGTMAN E.A.,
STEIJLEN P.M.
Publication year - 2010
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/j.1365-2354.2009.01102.x
Subject(s) - medicine , lymphangitis , lymphedema , cancer , lymphatic system , secondary lymphedema , dermatology , metastasis , surgery , pathology , breast cancer
DAMSTRA R.J., JAGTMAN E.A. & STEIJLEN P.M. (2010) European Journal of Cancer Care 19 , 669–675 Cancer‐related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature Lymphoedema is a clinical condition caused by impairment of the lymphatic system, leading to swelling of subcutaneous soft tissues. As a result, accumulation of protein‐rich interstitial fluid and lymphstasis often causes additional swelling, fibrosis and adipose tissue hypertrophy leading to progressive morbidity and loss of quality of life for the patient. Lymphoedema can be distinguished as primary or secondary. Lymphoedema is a complication frequently encountered in patients treated for cancer, especially after lymphadenoectomy and/or radiotherapy based on destruction of lymphatics. However, although lymphatic impairment is sometimes caused by obstructive solid metastasis, we present three cases of secondary lymphoedema with minor dermatological features without detectable solid metastasis. Sometimes this type of lymphoedema is mistakenly called malignant lymphoedema. All patients were previously treated for cancer without clinical signs of recurrence, presented with progressive lymphoedema and minor dermatological features of unknown origin. Clinical and histopathological examination of the skin revealed diffuse lymphangitis carcinomatosa, leading to secondary lymphoedema and adjustment of the therapeutic approach and prognosis. We reviewed literature on these rare presentations of cancer recurrence and recommend, where appropriate, consulting a dermatologist when discrete skin abnormalities are seen in patients with a history of cancer and developing lymphoedema.