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VEGF mRNA expression in jugulotympanic paraganglioma
Author(s) -
ZHANG X.,
XU W.,
SUN J.,
ZHANG K.
Publication year - 2010
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/j.1365-2354.2009.01098.x
Subject(s) - medicine , angiogenesis , messenger rna , paraganglioma , cytoplasm , vascular endothelial growth factor , vegf receptors , malignancy , pathology , vascular endothelial growth factor a , cancer research , microbiology and biotechnology , biology , gene , genetics
ZHANG X., XU W., SUN J. & ZHANG. K. (2010) European Journal of Cancer Care 19 , 816–819
VEGF mRNA expression in jugulotympanic paraganglioma The vascular endothelial growth factor (VEGF) family are essential regulators of angiogenesis and vascular permeability. VEGF protein was found in the jugulotympanic paraganglioma, but it wasn't confirmed on mRNA level. Our aim of this study is the mRNA expression of VEGF in jugulotympanic paraganglioma. We chose six cases of primary jugulotympanic paraganglioma wax specimen by hybridisation in situ . It suggested that VEGF mRNA had significant expression in the tumour cytoplasm of jugulotympanic paraganglioma. The correlation is not yet clear. It could be suggested the higher degree of malignancy, the stronger expression of VEGF mRNA in cytoplasm, but not found in the cellular nucleus.