Premium
Improvement of supportive nursing care in cancer patients autografted with bone marrow and mobilized peripheral blood haematopoietic progenitors
Author(s) -
GRECO MARIA GRAZIA,
BALBI MARINA,
SARACINO LUCIA,
MILANESI MARCO
Publication year - 1996
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/j.1365-2354.1996.tb00201.x
Subject(s) - medicine , mucositis , cyclophosphamide , haematopoiesis , bone marrow , total body irradiation , chemotherapy , cancer , oncology , melphalan , cytokine , progenitor cell , stem cell , biology , genetics
We report that in cancer patients a dramatic reduction in infection rate, days of isolation, oral mucositis and hospitalization due to high‐dose chemotherapy is achievable by autografting with haematopoietic progenitor cells (CPCs) circulating in peripheral blood following cancer therapy with high‐dose cyclophosphamide (HD‐CTX) and administration of recombinant haematopoietic cytokines. Thirty patients (29 lymphomas, one breast cancer) were treated with total body irradiation and high‐dose melphalan followed by either: (i) bone marrow transplant (Group A); (ii) bone marrow plus HD‐CTX‐mobilized CPC transplant (Group B); or (iii) bone marrow plus HD‐CTX‐ and cytokine‐mobilized CPC transplant (Group C). Nursing care load was remarkably higher in Group A patients compared to Group B and C patients, thus demonstrating clinical advantages of transplantation of HD‐CTX‐ and cytokine‐mobilized CPCs.