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Uncommon subtypes of borderline nuclear changes: cytological features and predictive value
Author(s) -
Evered A.
Publication year - 2007
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.2007.00500_9.x
Subject(s) - medicine , colposcopy , lesion , predictive value , cytology , gynecology , cervical screening , obstetrics , radiology , pathology , cervical cancer , cancer
In 2002 the British Society for Clinical Cytology proposed the introduction of borderline reporting category subtypes in the UK cervical screening programmes. Although yet to be implemented nationally the terms ‘borderline changes, high grade dyskaryosis cannot be excluded’ (BC‐H) and ‘borderline changes in endocervical cells’ (BC‐E) have been in use for some time at this centre. The aims of this study were to determine the frequency of use of BC‐H and BC‐E, to calculate their predictive value and to describe their morphological features. The reporting categories BC‐H and BC‐E are rarely used at this centre, each comprising just 0.05% of the routine cervical cytology workload and 1.4% of the borderline fraction. The predominant presentation of BC‐H in SurePath TM samples is that of hyperchromatic crowded cell groups. Approximately half these cases are associated with a significant cervical lesion (CIN2 or worse). BC‐E displays heterogeneous cytological features. Approximately 1 in 5 cases are associated with a significant histological lesion and only 1 in 10 cases harbour a significant glandular lesion (CGIN or worse).