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DIRECT‐TO‐VIAL USE OF THE LIQUI‐PREP™ CYTOLOGY SYSTEM
Author(s) -
Park J.,
Jung E.H.,
Kim C.,
Choi Y. H.
Publication year - 2006
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.2006.00392_13_1.x
Subject(s) - ascus (bryozoa) , medicine , vial , gynecology , cytology , liquid based cytology , obstetrics , cervical cancer , pathology , cancer , chemistry , chromatography , botany , ascospore , spore , biology
The authors initiated the use of Liqui‐PREP™ (LGM International Inc., Fort Lauderdale, FL, USA) in August, 2005. Cytotechnologists received extensive (one month) training by cytopathologists experienced in Liquid‐based cytology. The Liqui‐PREP™ direct‐to‐vial procedure (LP) was compared to the conventional Pap smears in a routine screening population. Methods: Data derived from 26 178 LP cervical‐vaginal (CV) specimens were compared to data derived from 218 548 conventional Pap smears (CS). Both data sets reflect patient samples collected concurrently (August–December, 2005) by 117 participating outpatient medical practices from a well‐defined geographic area. There were no significant personnel changes during the study period. The diagnostic results, classified according to Bethesda criteria were calculated. Results: % ASC‐US % ASC‐H % LSIL % HSIL+ ASCUS/ LSIL+ % Unsat.Liqui‐PREP™ 6.5 0.24 1.55 0.39 3.8 0.02 Conv. Smear 2.8 0.09 0.50 0.25 4.0 0.05Discussion: Liqui‐PREP™ direct‐to‐vial method for CV specimens identified 210% more LSIL and 56% more HSIL+ lesions compared to the conventional smears. The ASCUS rate was increased (perhaps due to the conservative nature of our staff and their cautious interpretation of a new preparation). The ratio of ASCUS to LSIL+ was reduced by 5% for Liqui‐Prep™. Available biopsy data showed high correlation between both LP and CS abnormal cytology diagnoses (94.1% and 89.9% respectively). These findings suggest that the Liqui‐PREP™ cytology preparation procedure identifies more pre‐malignant lesions than the conventional smear.