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Human papillomavirus DNA detection in women with primary abnormal cytology of the cervix: prevalence and distribution of HPV genotypes
Author(s) -
Beerens E.,
Van Renterghem L.,
Praet M.,
Sturtewagen Y.,
Weyers S.,
Temmerman M.,
Depypere H.,
Claeys P.,
Cuvelier C. A.
Publication year - 2005
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.2005.00266.x
Subject(s) - medicine , genotyping , cervix , human papillomavirus , genotype , cervical cancer , gynecology , hpv infection , squamous intraepithelial lesion , cytology , cervical screening , obstetrics , oncology , cancer , pathology , cervical intraepithelial neoplasia , biology , gene , genetics
Objectives: In this study, we focus on the prevalence and occurrence of different anogenital human papillomavirus (HPV) genotypes in a first abnormal cervical screening test, and correlate HPV genotyping with the cytological diagnosis on thin‐layer liquid‐based preparations in routine gynaecological screening. Methods: Out of 780 abnormal smears, 513 tested positive for HPV. All 25 different HPV types were identified by Line Probe Assay. Results: The prevalence of high‐risk HPV types increased from 72% in atypical squamous cell of undetermined significance to 94.5% in high‐grade intra‐epithelial lesion (HSIL). Co‐infection with multiple HPV types was predominantly found in HSIL (35.8%). In the HSIL group the most common HPV types were 16, 52, 51 and 31; type 18 was rarely present. Conclusion: The role of types 31, 51 and 52 should be considered in future studies on vaccine development.