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P‐cadherin expression in glandular lesions of the uterine cervix detected by liquid‐based cytology
Author(s) -
Longatto Filho A.,
Albergaria A.,
Paredes J.,
Moreira M. A. R.,
Milanezi F.,
Schmitt F. C.
Publication year - 2005
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.2004.00226.x
Subject(s) - cadherin , cytology , medicine , uterine cervix , cervix , gynecology , pathology , cell , biology , carcinoma , cancer , genetics
Objective: To study P‐cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P‐cadherin immunoexpression in liquid‐based cervical cytology samples of biopsy‐proven cervical lesions. Results: We found a statistically significant correlation between P‐cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous ( P < 0.0001). Twenty‐two of 33 malignant cases showed P‐cadherin membrane staining. None of the 30 benign cases tested showed membrane staining, but three of them displayed an aberrant nuclear P‐cadherin expression. Conclusions: We concluded that P‐cadherin can be used to discriminate between malignant and benign cervical cytological specimens, but not to discriminate glandular from squamous lesions.