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Cytomegalovirus Infection of the Cervix Detected By Cytology and Histology: A Report of Five Cases
Author(s) -
HUANG J. C.,
NAYLOR B.
Publication year - 1993
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.1993.tb00094.x
Subject(s) - asymptomatic , medicine , cytomegalovirus , cytology , biopsy , histology , pathology , human cytomegalovirus , cervix , betaherpesvirinae , herpesviridae , viral disease , virus , virology , cancer
We present four cases of cytomegalovirus (CMV) infection detected by cervical cytology of asymptomatic young women. One patient who had undergone bone marrow transplantation was immunosuppressed, but no factors predisposing to CMV infection were identified in the other three patients. A cervical biopsy specimen from a fifth patient, who was also asymptomatic, demonstrated the locus of CMV infection to be in endocervical gland cells. Immunocytochemical and polymerase chain reaction studies on this biopsy specimen confirmed that the histological changes were caused by CMV. the finding of CMV‐infected cells in cervical cytological or biopsy specimens is a rarity. Our observations in asymptomatic, non‐immunocompromised women suggest their presence is an incidental finding, unlikely to have any clinical significance.