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Medullary Carcinoma of Thyroid: A Re‐Evaluation of the Cytological Criteria of Diagnosis
Author(s) -
MENDONÇA M. E.,
RAMOS S.,
SOARES J.
Publication year - 1991
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.1991.tb00392.x
Subject(s) - medicine , pleomorphism (cytology) , papanicolaou stain , thyroid , pathology , medullary cavity , medullary carcinoma , thyroid nodules , thyroid carcinoma , cytology , carcinoma , cancer , immunohistochemistry , cervical cancer
We have reviewed the fine needle aspiration cytology appearances of a series of 31 consecutive and histologically confirmed medullary carcinomas of the thyroid. Despite the absence of a totally specific diagnostic feature, this retrospective re‐evaluation indicates that a preoperative diagnosis of medullary carcinoma of the thyroid is possible in almost every case. the features occurring most commonly include a dispersed cell pattern in which round or spindle shaped cells with eccentric speckled nuclei were seen showing slight pleomorphism with inconspicuous nucleoli. In a third of cases fine red granularity was present in the cytoplasm in slides stained with Giemsa and by the Papanicolaou technique.