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The number of nucleoli in benign and malignant thyroid lesions: a useful diagnostic sign in cytological preparations *
Author(s) -
MONTIRONI R.,
BRACCISCHI A.,
SCARPELLI M.,
SISTI S.,
MATERA G.,
MARIUZZI G. M.,
ALBERTI R.,
COLLAN Y.
Publication year - 1990
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.1990.tb00341.x
Subject(s) - nucleolus , pathology , medicine , thyroid , follicular phase , cytology , histology , thyroid nodules , adenoma , thyroid tumors , thyroid carcinoma , nucleus , malignancy , psychiatry
The slides of fine needle aspiration cytology specimens from 99 cases of cold thyroid nodules with known histology were reviewed and the number of nucleoli per nucleus counted and correlated with the different histopathological groups. Significant differences were observed between benign and malignant thyroid lesions in the number of nucleoli in the cytological material. Lower values were present in nodular goitres and follicular adenomas compared to carcinomas. In benign lesions the majority of nuclei contained one nucleolus and nuclei with two, three or more nucleoli were less frequent than in follicular, papillary, medullary and anaplastic carcinomas. Only one case of follicular adenoma had cells containing three or more nucleoli compared to more than half the cases of follicular carcinoma.