Premium
Amphicrine carcinoma of the lung. Diagnosis by fine needle aspiration cytology
Author(s) -
REDDY V.,
GATTUSO P.,
REYES C. V.,
CHINOY M.
Publication year - 1990
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1111/j.1365-2303.1990.tb00325.x
Subject(s) - medicine , fine needle aspiration cytology , carcinoma , fine needle aspiration , cytology , lung , radiology , general surgery , pathology , biopsy
A case of pulmonary carcinoma with dual (glandular and endocrine) differentiation diagnosed by fine needle aspiration cytology is reported. By light microscopy, the neoplastic cells showed mucicarmine, periodic‐acid Schiff, and Grimelius silver positivity. On immunostaining, neuron specific enolase, chromogranin, calcitonin and serotonin were demonstrated. Electron microscopy revealed two different types of distinctive cytoplasmic inclusions in the same cell, namely: carcinoid type of neurosecretory granules and mucin droplets. Diagnostic criteria and possible histogenesis of this rare tumour entity are discussed.