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Pregnancy‐associated plasma protein‐ A is related to gender and to adipocytokine levels: results of The Health Survey of Catalonia
Author(s) -
Joaquín Clara,
Granada Maria L.,
Pastor Cruz,
Castell Conxa,
Puig Rocío,
Alonso Núria,
Serra Enric,
Sanmartí Anna,
Foz Marius,
PuigDomingo Manel
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2012.04469.x
Subject(s) - adiponectin , adipokine , medicine , endocrinology , leptin , confounding , anthropometry , waist , insulin resistance , biomarker , pregnancy , body mass index , homeostasis , glucose homeostasis , homeostatic model assessment , waist–hip ratio , insulin , obesity , biology , biochemistry , genetics
Summary Objective Pregnancy‐associated plasma protein‐ A ( PAPP‐A ) is a protease promoting IGF 1 tissue availability and considered as a new biomarker of cardiovascular disease. Aim To evaluate the relationship between PAPP‐A concentrations and anthropometric variables, physical activity, smoking status, glucose homoeostasis and adipocytokines in healthy adults. Design and methods One hundred and forty‐nine subjects (77 women; mean age 39·7 ± 14 years; mean BMI 23·7 ± 1·9 kg/m 2 ) were randomly selected from 8000 adults of T he H ealth S urvey of C atalonia. Possible effects of gender, age, body composition, smoking status, physical activity, glucose homoeostasis and adipocytokines on PAPP‐A concentrations were assessed. Results Pregnancy‐associated plasma protein‐ A was significantly higher in men than in women [ 1·04 (0·61–0·44) vs 0·61 (0·41–0·90) μIU/ml; P < 0·0001]; there were no differences in relation to physical activity or smoking status. PAPP‐A showed a negative correlation with leptin in men ( P = 0·01) and women ( P = 0·05), and a positive correlation with adiponectin ( P = 0·006) in women and a trend ( P = 0·073) in men. Homoeostasis model assessment of insulin resistance ( HOMA‐IR ) showed a negative correlation with PAPP‐A only in women ( P = 0·019). No association was found with blood pressure, IGF 1, lipids or glucose in either gender. When a multiple regression analysis was performed including gender, age, BMI , waist‐hip ratio, HOMA‐IR , adiponectin and leptin as confounders, PAPP‐A was independently correlated with adiponectin (β = 0·23; P = 0·02) and leptin (β = −0·33; P = 0·04). Conclusions Our study shows a sexual dimorphism of PAPP‐A , and a possible influence of leptin and adiponectin on its concentrations in healthy subjects. The mechanisms responsible for this relationship remain to be determined.