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Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the K orean S arcopenic O besity S tudy
Author(s) -
Kim Tae Nyun,
Park Man Sik,
Lim Kang Il,
Choi Hae Yoon,
Yang Sae Jeong,
Yoo Hye Jin,
Kang Hyun Joo,
Song Wook,
Choi Hyuk,
Baik Sei Hyun,
Choi Dong Seop,
Choi Kyung Mook
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2012.04433.x
Subject(s) - insulin resistance , medicine , sarcopenia , endocrinology , vitamin d and neurology , obesity , sarcopenic obesity , body mass index , homeostasis
Summary Objective It has been suggested that insulin resistance, low‐grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity ( SO ) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance ( HOMA ‐ IR ), high‐sensitivity C ‐reactive protein (hs CRP ) and 25‐hydroxyvitamin D (25[ OH ] D ) levels on SO in K orean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the K orean S arcopenic O besity S tudy. S arcopenia was defined as a skeletal muscle mass index ( SMI ) of 1 SD below the sex‐specific mean value for a young reference group. Obesity was defined as a visceral fat area ( VFA ) ≥100 cm 2 . We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA . Results The prevalence of SO was 17·8% in men and 24·9% in women. In women, the SO group had higher HOMA ‐ IR and hs CRP levels compared with the non‐ SO group. In men, the 25[ OH ] D levels were significantly lower in the SO group than the non‐ SO group. Both hs CRP and HOMA ‐ IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[ OH ] D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA ‐ IR and 25[ OH ] D levels were independently associated with SO in men, while HOMA ‐ IR and hs CRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a K orean adult population.