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Total testosterone may not decline with ageing in K orean men aged 40 years or older
Author(s) -
Kim YoungSang,
Hong Doohee,
Lee DuckJoo,
Joo NamSeok,
Kim KwangMin
Publication year - 2012
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2012.04375.x
Subject(s) - ageing , medicine , body mass index , endocrinology , waist , diabetes mellitus , testosterone (patch) , anthropometry , healthy ageing , gerontology
Summary Objective It is generally believed that gonadal function in men declines with ageing. However, observations on ageing‐related decrease in total testosterone ( TT ) are not consistent. The aim of this study is to examine the ageing‐related changes of testosterone and to investigate the influence of the ageing‐related factors on TT . Design Changes of TT with ageing were observed in longitudinal design in a single health promotion centre. Subjects A total of 220 K orean men aged ≥40 years were included between 2002 and 2011. TT assay was repeated for all subjects, with an interval of ≥3 years. Measurements Information of medical history and lifestyle habits was collected. Anthropometry and blood pressure were measured. TT , glucose, creatinine, highly sensitive C ‐reactive protein, liver enzymes and lipid profiles were tested. Results Mean TT level did not decline significantly with ageing during median 4·3 years follow‐up (18·1 vs 17·8 n m , P = 0·439). Longitudinal change of TT was approximately + 0·8% per year. TT was negatively correlated with body mass index ( BMI ), waist circumference and glucose. With mixed effects model, diabetes ( P = 0·038) and BMI ( P = 0·007) affected TT level, but age and follow‐up interval did not. Conclusions TT did not change significantly in 220 K orean men for a median 4·3 years follow‐up. TT was not influenced by the age and follow‐up interval. BMI and diabetes mellitus affected TT decline.