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The relationship between coronary risk factors and elevated 1‐h postload plasma glucose levels in patients with established coronary heart disease
Author(s) -
Wu Xing,
Chen Hui,
Wang Yongliang,
Li Hongwei
Publication year - 2013
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2012.04362.x
Subject(s) - medicine , blood pressure , diabetes mellitus , triglyceride , body mass index , cardiology , coronary angiography , type 2 diabetes , coronary artery disease , coronary heart disease , cholesterol , plasma glucose , endocrinology , gastroenterology , myocardial infarction
Summary Objective Recent studies have shown that an elevated 1‐h postload plasma glucose (1h PG ) is able to identify subjects with normal glucose tolerance ( NGT ) at high risk for future type 2 diabetes and atherosclerotic cardiovascular disease. However, clinical studies about the characteristics of coronary heart disease ( CHD ) patients with elevated 1h PG are lacking. The aim of this study was to analyse the 1h PG level in CHD patients with NGT . Methods A total of 204 CHD patients with NGT were recruited. Subjects underwent an oral glucose tolerance test, echocardiography and coronary angiography. Demographic data were recorded and blood samples obtained. According to the 1h PG cut‐off point of 8·6 m m , patients were divided into two groups: 1h PG ≥ 8·6 m m ( n = 65) and 1h PG < 8·6 m m ( n = 139). Results Compared with the 1h PG < 8·6 m m group, subjects with 1h PG ≥ 8·6 m m had a worse metabolic profile, exhibiting significantly higher body mass index, systolic blood pressure, triglyceride level and lower HDL ‐cholesterol level. Plasma high‐sensitivity CRP (hs CRP ) levels were higher in the 1h PG ≥ 8·6 m m group than in the 1h PG < 8·6 m m group. Coronary angiography revealed that single‐vessel changes were more frequent in the 1h PG < 8·6 m m group, but there were no significant differences in the G ensini score. Conclusions Patients with CHD with 1h PG ≥ 8·6 m m have a worse metabolic profile, higher levels of hs CRP and multi‐vessel coronary atherosclerosis. These findings suggest that, in patients with CHD , elevated 1h PG increases coronary risk factors and may be a marker for early‐stage glucose intolerance.