Premium
Levels of fetuin‐A relate to the levels of bone turnover biomarkers in male and female patients with type 2 diabetes
Author(s) -
Rasul Sazan,
Ilhan Aysegul,
Reiter Marie H.,
Todoric Jelena,
Farhan Serdar,
Esterbauer Harald,
KautzkyWiller Alexandra
Publication year - 2012
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2011.04246.x
Subject(s) - medicine , endocrinology , n terminal telopeptide , bone remodeling , osteocalcin , type 2 diabetes , diabetes mellitus , osteoporosis , creatinine , alkaline phosphatase , biology , biochemistry , enzyme
Summary Objective To evaluate the relationship of plasma fetuin‐A levels with markers of bone turnover in male and female type 2 diabetic subjects. Background Fetuin‐A, which is a serum protein produced by the liver and promotes bone mineralization, is an independent risk factor for type 2 diabetes, whilst type 2 diabetes is associated with an increased incidence of osteoporosis or fractures. It is not known how fetuin‐A levels relate to parameters of bone metabolism in type 2 diabetes. Design and patients Eighty patients with type 2 diabetes [40 men and 40 women matched for age, body mass index (BMI) and time since diagnosis of diabetes] were studied. Fetuin‐A together with metabolic parameters and levels of serum carboxy‐terminal telopeptide of type 1 collagen (C‐telopeptide), osteocalcin, procollagen type 1 amino‐terminal propeptide (P1NP), bone alkaline phosphatase (ALP) and sex hormones was determined in all participants. Results Fetuin‐A levels did not differ significantly between male and female diabetic subjects. In a model adjusted for age, BMI, fatty liver index (FLI), time since diagnosis of diabetes, HbA 1c , antidiabetic and lipid‐lowering drug therapies, smoking, total serum protein, creatinine, gamma glutamyl‐transferase, parathyroid hormone, C‐reactive protein, glomerular filtration rate, and presence of micro‐, cardio‐, and peripheral vascular diabetic complications, fetuin‐A showed a significant positive association with levels of bone ALP ( r = 0·71, P = 0·006) in men. In women, fetuin‐A was significantly negatively associated with C‐telopeptide ( r = −0·60, P = 0·03) levels. Conclusions Results suggest an independent association of fetuin‐A levels with markers of bone turnover in male and female patients with type 2 diabetes. More studies are needed to determine whether fetuin‐A could serve as a new marker for fracture risk or osteoporosis in type 2 diabetes and to explore its potential sexually dimorphic effects.