Premium
Hyperinsulinemia acutely increases serum macrophage inhibitory cytokine‐1 concentration in anorexia nervosa and obesity
Author(s) -
KarczewskaKupczewska Monika,
Kowalska Irina,
Nikolajuk Agnieszka,
Adamska Agnieszka,
Otziomek Elzbieta,
Gorska Maria,
Straczkowski Marek
Publication year - 2012
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2011.04139.x
Subject(s) - medicine , endocrinology , hyperinsulinemia , obesity , insulin resistance , population , macrophage migration inhibitory factor , cytokine , environmental health
Summary Context Macrophage inhibitory cytokine‐1 (MIC‐1) plays a role in the regulation of cellular responses to stress signals and inflammation. MIC‐1 has also been implicated in mediation of tumour‐induced anorexia and weight loss. Increased serum concentrations of MIC‐1 were found in patients with anorexia nervosa (AN), obesity and type 2 diabetes. Objective To estimate serum MIC‐1 concentration in women with AN and obese women, its regulation by hyperinsulinemia and relationship with insulin sensitivity. Patients We examined 20 women with AN, 28 healthy normal‐weight female controls and 28 obese women. Measurements Serum MIC‐1 concentration was measured in the fasting state and after 2‐h euglycemic hyperinsulinemic clamp. Results At baseline, serum MIC‐1 was higher in AN in comparison with other groups (normal‐weight, P = 0·018; obese, P = 0·01). Hyperinsulinemia resulted in a significant increase in serum MIC‐1 concentration in the entire study population ( P < 0·001) and in AN ( P < 0·001), normal‐weight ( P = 0·002) and obese ( P < 0·001) groups analysed separately. Postclamp serum MIC‐1 was still higher in AN women in comparison with other groups (normal‐weight, P = 0·012; obese, P = 0·023). When normal‐weight and obese women were analysed together, with the exclusion of AN group, an inverse correlation between insulin sensitivity and the change in serum MIC‐1 during the clamp was observed ( r = −0·27, P = 0·042). Conclusions Hyperinsulinemia resulted in a significant increase in serum MIC‐1 in different states of adiposity. Increased serum MIC‐1 in AN women might be an additional factor responsible for weight loss in this group.