Premium
Serum fetuin‐A concentrations are elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes
Author(s) -
Ou HorngYih,
Yang YiChing,
Wu HungTsung,
Wu JinShang,
Lu FengHwa,
Chang ChihJen
Publication year - 2011
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2011.04070.x
Subject(s) - medicine , endocrinology , impaired glucose tolerance , impaired fasting glucose , type 2 diabetes , fetuin , diabetes mellitus , adiponectin , nonalcoholic fatty liver disease , fatty liver , insulin resistance , steatosis , biology , disease , microbiology and biotechnology , glycoprotein
Summary Objective Hepatic steatosis is associated with an increased risk of diabetes. Although the levels of serum fetuin‐A, a liver‐derived glycoprotein that impairs insulin signalling, are positively correlated with hepatic steatosis, the levels of fetuin‐A in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes (NDD) have not been established. The aim of this study is to investigate the relationship among serum fetuin‐A concentrations, IFG, IGT and NDD in Chinese subjects without nonalcoholic fatty liver disease (NAFLD). Design A total of 360 age‐ and sex‐matched subjects with normal glucose tolerance (NGT), IFG, IGT and NDD were recruited in this case–control study. Measurements Each subject was assessed by abdominal ultrasound to exclude the presence of NAFLD. Serum fetuin‐A concentrations were measured by enzyme‐linked immunosorbent assay and compared between NGT, IFG, IGT and NDD groups. The association with clinical and metabolic parameters was also examined. Results Serum fetuin‐A concentrations were higher in NDD and IGT groups than NGT groups (341 ± 88, 335 ± 90, and 300 ± 75 μg/ml). In multiple linear regression analysis, IGT ( P < 0·01) and NDD ( P < 0·05) were the positively associated factors of serum fetuin‐A concentrations, but age ( P < 0·05) was a negatively associated factor after adjusting for age, anthropometric indices, lipid profile, estimated glomerular filtration rate (eGFR), adiponectin, C‐reactive protein (CRP) and homeostasis model assessment (HOMA‐IR). Conclusions IGT and NDD are positively associated with serum fetuin‐A concentrations in subjects without NAFLD independent of cardiometabolic risk factors.