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Genetic effects of adiponectin on blood lipids and blood pressure
Author(s) -
Zhao Tongfeng,
Zhao Jiangpei
Publication year - 2011
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2010.03902.x
Subject(s) - adiponectin , medicine , confidence interval , blood pressure , meta analysis , blood lipids , endocrinology , type 2 diabetes , polymorphism (computer science) , diabetes mellitus , biology , cholesterol , allele , insulin resistance , obesity , gene , genetics
Summary Objective Results from the published studies on the association of adiponectin gene ( ADIPOQ ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and −11377 C > G (rs266729), with these traits in this meta‐analysis. Research design and methods We included 35 studies in this meta‐analysis. Dominant models were used for this meta‐analysis. Results We did not detect a significant association of the −11377 C > G polymorphism with blood lipids or blood pressure ( P > 0·05). The association of the +45 T > G polymorphism with blood lipids and blood pressure was, similarly, not significant ( P > 0·05). The meta‐analysis suggested a significant overall association of the +276 G > T polymorphism with lower levels of total cholesterol: weighted mean difference (WMD) = −0·10, 95% confidence interval (CI, −0·17, −0·03), P = 0·005, P heterogeneity = 0·04. This association was marginally significant in East Asians and East Asians with type 2 diabetes: WMD = −0·10, 95% CI (−0·20, 0·00), P = 0·05, P heterogeneity = 0·002, and WMD = −0·09, 95% CI (−0·18, −0·00), P = 0·05, P heterogeneity = 0·80, respectively. After exclusion of a study that was the source of heterogeneity, the association was significant in overall populations and marginally significant in East Asians: WMD= ‐0·06, 95% CI (−0·11, −0·01), P = 0·01, P heterogeneity = 0·98, and WMD = −0·06, 95% CI (−0·12, 0·00), P = 0·07, P heterogeneity = 0·83, respectively. However, none of these associations were significant after Bonferroni correction (significant threshold: P < 0·003). Conclusions Our meta‐analysis does not suggest any association of the three ADIPOQ polymorphisms with blood lipids and blood pressure.