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Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)
Author(s) -
Yu Ning,
Donnan Peter T.,
Flynn Robert W. V.,
Murphy Michael J.,
Smith David,
Rudman Andrew,
Leese Graham P.
Publication year - 2010
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2009.03766.x
Subject(s) - medicine , primary hyperparathyroidism , epidemiology , population , standardized mortality ratio , incidence (geometry) , hyperparathyroidism , retrospective cohort study , cohort study , mortality rate , pediatrics , surgery , physics , environmental health , optics
Summary Objective To describe mortality and disease‐specific morbidities in patients with mild primary hyperparathyroidism (PHPT). Design Retrospective population‐based observational study. Setting Tayside, Scotland, from 1997 to 2006. Participants Patients with mild PHPT were selected from a predefined PHPT cohort between 1997 and 2006. Main outcome measures Standardised mortality ratios (SMRs) were examined for all‐cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co‐morbidities. Results In total, there were 1683 (69·1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all‐cause mortality and cardiovascular mortality (SMR‐all cause 2·62, 95% CI 2·39–2·86; SMR‐cardiovascular 2·68, 95% CI 2·34–3·05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age‐ and sex‐adjusted general population. Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.