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Low density lipoprotein receptor‐related protein 5 ( LRP5 ) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia
Author(s) -
Saarinen Anne,
Saukkonen Tero,
Kivelä Tero,
Lahtinen Ulla,
Laine Christine,
Somer Mirja,
ToiviainenSalo Sanna,
Cole William G.,
Lehesjoki AnnaElina,
Mäkitie Outi
Publication year - 2010
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2009.03680.x
Subject(s) - endocrinology , medicine , lrp5 , osteoporosis , impaired glucose tolerance , diabetes mellitus , insulin resistance , glucose homeostasis , biology , wnt signaling pathway , genetics , gene
Summary Objective Mutations in the low‐density lipoprotein receptor‐related protein 5 gene ( LRP5 ) underlie osteoporosis–pseudoglioma syndrome. Animal models implicate a role for LRP5 in lipid and glucose homeostasis. The objective was to evaluate metabolic consequences of LRP5 mutations in humans. Design and patients Thirteen Finnish individuals with homozygous or heterozygous LRP5 mutations were assessed for bone health, glucose and lipid metabolism, and for serum serotonin concentration. Results were compared with findings in family members without mutations. Measurements Bone mineral density (BMD), vertebral morphology, oral and intravenous glucose tolerance tests, lipid profile and serum serotonin concentrations. Results Two individuals were homozygous for R570W, one compound heterozygous for R570W and R1036Q, and 10 were heterozygous (six for R570W, three for R1036Q and one for R925C). Subjects with two LRP5 mutations had multiple spinal fractures and low BMD. Subjects with one mutation had significantly lower median lumbar spine ( P = 0·004) and femoral neck ( P = 0·005) BMD Z‐scores, and more often vertebral fractures than the 18 individuals without mutations. Of the 12 subjects with LRP5 mutation six had diabetes and one had impaired glucose tolerance. Intravenous glucose tolerance tests suggested impaired beta‐cell function; no insulin resistance was observed. Prevalence of hypercholesterolaemia was similar in mutation positive and negative subjects. Serum serotonin concentrations showed a trend towards higher concentrations in subjects with LRP5 mutation. Conclusions We found high prevalence of osteoporosis and abnormal glucose metabolism in subjects with LRP5 mutation(s). Further studies are needed to establish the role of LRP5 in glucose and lipid metabolism.