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Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans
Author(s) -
ValiñaTóth Anna Liza B.,
Lai Zongshan,
Yoo Wonsuk,
AbouSamra Abdul,
Gadegbeku Crystal A.,
Flack John M.
Publication year - 2010
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2009.03676.x
Subject(s) - medicine , endocrinology , parathyroid hormone , vitamin d and neurology , anthropometry , overweight , body mass index , obesity , vitamin d deficiency , fat mass , calcium
Summary Background Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25‐hydroxyvitamin D (25‐OH D) and elevated parathyroid hormone (PTH). The relationship of 25‐OH D and PTH with body composition and size in AA is not well known. Objective To determine the relationship of 25‐OH D and PTH levels with body composition and anthropometric measures. Design A cross‐sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS‐sponsored weight loss/salt‐sensitivity trial. Measurements Multivariable linear regression analyses were used to explore the relationship of 25‐OH D and PTH with body composition, determined by dual‐energy X‐ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25‐OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25‐OH D and normal PTH and (iii) low 25‐OH D and high PTH. Results Age, gender and season‐adjusted regression analyses showed that PTH was directly correlated with total ( P = 0·02), truncal ( P = 0·03) and extremity ( P = 0·03) fat mass, while 25‐OH D was inversely related to truncal fat mass ( P = 0·02). Total fat mass in groups 1–3, respectively, was 30·0, 34·0 and 37·4 kg ( P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg ( P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg ( P = 0·02). Lean mass did not differ across the three groups. Conclusions Our findings show that lower 25‐OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.