Premium
Association of insulin resistance with anti‐Mullerian hormone levels in women without polycystic ovary syndrome (PCOS)
Author(s) -
Park Hyun T.,
Cho Geum J.,
Ahn Ki H.,
Shin Jung H.,
Kim Young T.,
Hur Jun Y.,
Kim Sun H.,
Lee Kyu W.,
Kim Tak
Publication year - 2010
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2009.03614.x
Subject(s) - medicine , insulin resistance , polycystic ovary , endocrinology , adipokine , anti müllerian hormone , adiponectin , insulin , luteinizing hormone , hormone
Summary Objective To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti‐Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS). Design/patients/measurements We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA‐IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles. Results Higher HOMA‐IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA‐IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA‐IR was independently associated with AMH. Conclusion An independent relationship exists between HOMA‐IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.