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Androgenetic alopecia and insulin resistance in young men
Author(s) -
GonzálezGonzález José Gerardo,
MancillasAdame Leonardo G.,
FernándezReyes Mercedes,
GómezFlores Minerva,
LavalleGonzález Fernando Javier,
OcampoCandiani Jorge,
VillarrealPérez Jesús Zacarías
Publication year - 2009
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2008.03508.x
Subject(s) - insulin resistance , medicine , body mass index , endocrinology , metabolic syndrome , blood pressure , quantitative insulin sensitivity check index , obesity , insulin , free androgen index , homeostatic model assessment , insulin sensitivity , polycystic ovary
Summary Background Epidemiological studies have associated androgenetic alopecia (AGA) with severe young‐age coronary artery disease and hypertension, and linked it to insulin resistance. We carried out a case–control study in age‐ and weight‐matched young males to study the link between AGA and insulin resistance using the homeostasis model assessment of insulin resistance (HOMA‐IR) index or metabolic syndrome clinical manifestations. Methods Eighty young males, 18–35 years old, with AGA ≥ stage III in the Hamilton–Norwood classification, and 80 weight‐ and age‐matched controls were included. Alopecia, glucose, serum insulin, HOMA‐IR index, lipid profile and androgen levels, as well as metabolic syndrome criteria, were evaluated. Results The HOMA‐IR index was significantly higher in cases than controls. Nonobese cases had a higher mean diastolic blood pressure and a more frequent family history of AGA than nonobese controls. A borderline difference in the HOMA‐IR index was found in obese AGA cases vs. obese controls [ P = 0·055, 95% confidence interval (CI) 2·36–4·20 vs. 1·75–2·73]. Free testosterone values were significantly higher in controls than cases, regardless of body mass index (BMI). A statistically significant additive effect for obesity plus alopecia was found, with significant trends for insulin, the HOMA‐IR index, lipids and free testosterone when BMI and alopecia status were used to classify the participants. Conclusions Our results support the recommendation for assessing insulin resistance and cardiovascular‐related features and disorders in all young males with stage III or higher AGA, according to the Hamilton–Norwood classification.