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Ghrelin suppresses secretion of FSH in males
Author(s) -
Kluge Michael,
Uhr Manfred,
Bleninger Philipp,
Yassouridis Alexander,
Steiger Axel
Publication year - 2009
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2008.03440.x
Subject(s) - ghrelin , endocrinology , medicine , secretion , placebo , hormone , alternative medicine , pathology
Summary Background Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH. Objective Our objective was to study the effect of ghrelin on secretion of FSH in humans. Design/study subjects Nocturnal (20:00–07:00 h) secretion profiles of FSH were measured in 10 healthy males (25·3 ± 3·2 years) twice, receiving 50 µg ghrelin or placebo at 22:00, 23:00, 24:00, and 01:00 h, in this single‐blind, randomized, cross‐over study. Results Mean FSH plasma levels were significantly ( P < 0·05) lower with ghrelin than placebo between 01:00 and 02:20. Consistently, a significant decrease from baseline was only observed in the ghrelin but not in the placebo condition. Conclusion This study provides first evidence that ghrelin suppresses the secretion of FSH in humans.