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Cross‐sectional analysis of testosterone therapies in hypopituitary men on stable pituitary hormone replacement
Author(s) -
Siyambalapitiya S.,
Jonsson P.,
KoltowskaHaggstrom M.,
Gaillard R.,
Ho K.,
Ross R. J. M.
Publication year - 2009
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2008.03435.x
Subject(s) - testosterone (patch) , testosterone replacement , hormone replacement therapy (female to male) , medicine , endocrinology , androgen , regimen , hypopituitarism , hormone
Summary Objective The last decade has seen a proliferation in options for testosterone replacement. However, little is known as to the benefits of different treatment modalities. Our objective was to determine the testosterone prescription pattern and to examine the impact on various outcome measures. Subjects and methods A total of 816 adult‐onset hypopituitary males on stable pituitary replacement for at least 1 year were identified from the KIMS database. Patients were classified as either eugonadal ( n = 106), or hypogonadal ( n = 710) on intramuscular (IM, n = 558), oral ( n = 74), transdermal ( n = 61), and depot ( n = 17) testosterone. Results After 1 year of stable pituitary replacement therapy, body composition, cardiovascular parameters, GH replacement and quality of life were not significantly different in androgen‐replaced hypogonadal patients compared to eugonadal patients. There were no differences in outcome variables within the hypogonadal group according to the testosterone replacement regimen used and no difference in response to GH therapy. Conclusions The majority of hypopituitary patients in the last decade have received IM testosterone. Body composition, cardiovascular parameters, GH replacement and quality of life were not different between eugonadal and hypogonadal patients and were not differentially affected by the mode of testosterone replacement. These findings are reassuring that there is no major difference in response to different testosterone replacement regimens.