Premium
Changes in adiponectin multimer distribution in response to atorvastatin treatment in patients with type 2 diabetes
Author(s) -
Von Eynatten M.,
Liu D.,
Bluemm A.,
Schuster T.,
Baumann M.,
Lutz J.,
Heemann U.,
Dugi K. A.,
Nawroth P. P.,
Bierhaus A,
Humpert P. M.
Publication year - 2009
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2008.03412.x
Subject(s) - adiponectin , atorvastatin , medicine , endocrinology , type 2 diabetes , diabetes mellitus , chemistry , insulin resistance
Summary Objective Multimeric high molecular weight (HMW) forms of adiponectin were previously shown to be inversely associated with the extent of atherosclerosis in males and are down‐regulated in patients with the metabolic syndrome and type 2 diabetes. In this study, potential influences of atorvastatin therapy on adiponectin multimer distribution were studied in patients with type 2 diabetes. Design, patients and measurements The effect of 40 mg atorvastatin on HMW, medium molecular weight (MMW), and low molecular weight (LMW) isoforms of adiponectin were investigated in 75 patients (23 females; 52 males) with type 2 diabetes in an 8‐week‐long, placebo‐controlled and randomized study. Adiponectin multimeric isoforms were detected by Western blot analysis. Results After atorvastatin therapy the median serum concentration of HMW adiponectin increased significantly by 42·3% (1·68 vs. 2·39 µg/ml; P < 0·001), while concentrations of MMW adiponectin and LMW adiponectin significantly decreased by 20·8% and 23·2%, respectively (MMW: 3·31 vs. 2·62 µg/ml, P = 0·047; LMW: 0·56 vs. 0·43 µg/ml, P = 0·033). Median total adiponectin levels were not significantly altered by atorvastatin treatment (6·0 vs. 6·2 µg/ml, P = 0·898). Consequently, the HMW : total‐adiponectin ratio significantly increased by 25·0% (0·40 vs. 0·50; P = 0·013). Conclusions Atorvastatin therapy is associated with significant changes in adiponectin multimer distribution in patients with type 2 diabetes. Since total adiponectin levels were not affected by intervention, atorvastatin may shift adiponectin size towards the HMW form.