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Interleukin‐6 ( IL‐6 ) –572C→G promoter polymorphism is associated with type 2 diabetes risk in Koreans
Author(s) -
Koh Soo Jeong,
Jang Yangsoo,
Hyun Yae Jung,
Park Ju Yeon,
Song Young Duk,
Shin KyungKyun,
Chae Jey Sook,
Kim ByungKeuk,
Ordovas Jose M.,
Lee Jong Ho
Publication year - 2009
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2008.03315.x
Subject(s) - medicine , genotype , odds ratio , endocrinology , allele , diabetes mellitus , case control study , polymorphism (computer science) , gastroenterology , biology , gene , genetics
Summary Objective Increased levels of inflammatory markers, such as interleukin‐6 ( IL ‐6), are associated with type 2 diabetes (T2DM). We investigated the association of IL‐6 gene polymorphisms with T2DM and circulating levels of IL ‐6 in Koreans. Subjects A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included. Measurements We examined IL‐6 – 174G→C, –572C→G, –597G→A and –1363G→T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL ‐6 and high‐sensitivity C‐reactive protein (hs‐CRP). Results Homozygosity for the rare G allele IL‐6 – 572C→G was associated with a higher risk of T2DM [OR 1·69 (95%CI 1·11–2·58), P = 0·015]. Serum IL ‐6 concentrations were associated with the IL‐6 – 572C→G genotype in control subjects (G/G: 2·33 ± 0·41: C/G: 1·53 ± 0·09: C/C: 1·72 ± 0·08 ng/l, P = 0·023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs‐CRP than C/C and C/G carriers (G/G: 13·6 ± 2·9: C/G: 9·2 ± 0·6: C/C: 7·8 ± 0·4 mg/l, P = 0·003). The C‐allele at the IL‐6 – 174 SNP was very rare (< 0·01) and –597G→A and –1363G→T were monomorphic in this population. Conclusions Our data demonstrate that the IL‐6 – 572G/G genotype is associated with higher serum IL ‐6 and hs‐CRP concentrations and with increased risk for T2DM.