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Serum levels of the adipokine visfatin are increased in pre‐eclampsia
Author(s) -
Fasshauer Mathias,
Waldeyer Theresa,
Seeger Jeannette,
Schrey Susanne,
Ebert Thomas,
Kratzsch Jurgen,
Lossner Ulrike,
Bluher Matthias,
Stumvoll Michael,
Faber Renaldo,
Stepan Holger
Publication year - 2008
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2007.03147.x
Subject(s) - medicine , adipokine , endocrinology , insulin resistance , creatinine , gestational diabetes , insulin , blood pressure , metabolic syndrome , obesity , pregnancy , gestation , biology , genetics
Summary Objective Pre‐eclampsia (PE) is a serious cardiovascular complication in pregnancy which shares risk factors with the metabolic syndrome including insulin resistance and obesity. Recently, visfatin was introduced as a novel insulin‐mimetic adipokine which is up‐regulated when weight is gained. In the current study, we investigated visfatin serum levels in pre‐eclamptic patients as compared to healthy gestational age‐matched controls. Patients and measurements Visfatin was quantified by ELISA in control ( n = 20) and PE ( n = 15) patients. Furthermore, visfatin was correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation. Results Mean maternal visfatin serum levels adjusted for maternal age were about twofold up‐regulated in PE (31·1 ± 23·4 µg/l) as compared to controls (15·7 ± 23·1 µg/l). Furthermore, visfatin concentrations correlated positively with age, blood pressure, creatinine, free fatty acids (FFA), IL‐6 and C reactive protein (CRP), whereas a negative correlation was found with fasting insulin and the HOMA‐insulin resistance index (HOMA‐IR). In multivariate analyses, HOMA‐IR and CRP remained independently associated with visfatin serum levels and explained 58% of the variation in visfatin concentrations. Conclusions We show that maternal visfatin levels are significantly increased in PE patients. Furthermore, insulin sensitivity and inflammatory status independently predict serum visfatin levels.