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Total, free and bound leptin and thyroid function in elderly women with different body weights
Author(s) -
Ruscica Massimiliano,
Dozio Elena,
Gandini Sara,
Gnocchi Pierluigi,
Devalle Guya Giuseppina,
Motta Marcella,
Roti Elio,
Magni Paolo
Publication year - 2008
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2007.03133.x
Subject(s) - leptin , medicine , endocrinology , euthyroid , thyroid function , overweight , adipose tissue , body mass index , obesity , underweight , thyroid , chemistry
Summary Objective The present study was aimed at evaluating the relationship of total leptin, and its free leptin (FL) and bound leptin (BL) fractions with adipose mass in very old euthyroid women, in relationship to thyroid function. Subjects and methods Twenty‐five older women (age: 73–95 years) were studied. Subjects representing underweight, normal weight and overweight/obese conditions were included. Plasma leptin, TSH, free T 4 (FT 4 ) and free T 3 , (FT 3 ) total and HDL cholesterol were measured. FL and BL were evaluated by Fast Protein Liquid Chromatography (FPLC) analysis. Results Plasma leptin concentration was positively correlated with body mass index (BMI) ( r = 0·64, P = 0·0005) and tricipital skin‐fold thickness (TF) ( r = 0·46, P = 0·0187). Leptin was positively correlated with TSH ( r = 0·50, P = 0·0116) and inversely with FT 3 ( r = – 0·40, P = 0·0477). TSH correlated with the adiposity indexes BMI ( r = 0·40, P = 0·05) and TF ( r = 0·42, P = 0·0336). Plasma FT 3 was positively correlated with FT 4 ( r = 0·49, P = 0·012). FL and BL were evaluated in 8 out of 25 subjects. FL positively correlated with BMI ( r = 0·81, P = 0·0218) and leptin ( r = 0·83, P = 0·0004), whereas BL did not correlate with these parameters. Conclusions The present results indicate that in very old women, plasma leptin concentrations reflect the extent of adipose mass and suggest that a complex regulatory interaction exists between leptin and thyroid function, possibly taking place at central (hypothalamus–pituitary) and peripheral (deiodinase activity) levels.