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Glycohaemoglobin as a determinant of increased fibrinogen concentrations and low‐grade inflammation in apparently healthy nondiabetic individuals
Author(s) -
Rogowski Ori,
Shapira Itzhak,
Peretz Hava,
Berliner Shlomo
Publication year - 2008
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2007.03017.x
Subject(s) - fibrinogen , medicine , body mass index , endocrinology , c reactive protein , waist , inflammation , diabetes mellitus , coronary artery disease , blood pressure , physiology
Summary Objective To determine the potential role of glycohaemoglobin as a possible determinant of increased fibrinogen concentrations and low‐grade inflammation in a group of apparently healthy, nondiabetic individuals not expressing clinically overt atherothrombosis. Design and Main Outcome Measures We performed a cross‐sectional analysis of the concentrations of glycohaemoglobin alongside the concentrations of quantitative fibrinogen and high‐sensitivity C‐reactive protein (hs‐CRP). In all, 1511 males and 757 apparently healthy females, without diabetes mellitus or clinically evident atherothrombotic disease, were enrolled in the study during their routine annual health check‐up. Results Glycohaemoglobin entered the linear regression models as a significant determinant of quantitative fibrinogen in both genders and of hs‐CRP in men. We found this to be true even following the inclusion of multiple variables known to influence the intensity of low‐grade inflammation, such as age, gender, waist circumference, body mass index, blood pressure, medications, hormone therapy, glucose levels (normal or impaired fasting glucose), smoking habits, family history of coronary artery disease, lipid profile as well as alcohol consumption and sports intensity. We found glycohaemoglobin to be a significant determinant of fibrinogen concentrations in apparently healthy nondiabetic individuals not yet presenting with evident atherothrombosis. Conclusions This observation supports the idea that glycohaemoglobin might have an effect on fibrinogen concentrations in both genders and on hs‐CRP in men. Moreover, our results suggest that glycohaemoglobin should be perceived as a continuous variable without a ‘normal’ cut‐off point, as it may exhibit a detrimental role even when present in relatively low levels.