Premium
Correlation of serum IGF‐I and IGFBP‐1 and ‐3 to cardiovascular risk indicators and early carotid atherosclerosis in healthy middle‐aged men
Author(s) -
Boquist S.,
Ruotolo G.,
SkoglundAndersson C.,
Tang R.,
Björkegren J.,
Bond M. G.,
De Faire U.,
Brismar K.,
Hamsten A.
Publication year - 2008
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2007.02998.x
Subject(s) - medicine , endocrinology , immunoradiometric assay , postprandial , radioimmunoassay , apolipoprotein b , risk factor , cholesterol , insulin
Summary Objectives IGF‐I, IGFBP‐1 and IGFBP‐3 are putative mediators in cardiovascular disease. The present study examined (i) the correlations of circulating IGF‐I, IGFBP‐1 and IGFBP‐3 to established cardiovascular risk factors and signs of early atherosclerosis as reflected by ultrasound measurement of common carotid intima–media thickness (IMT), and (ii) whether serum concentrations of these analytes are modulated during alimentary lipaemia. Design Cross‐sectional clinical study. Patients A biobank and clinical database based on 96 healthy Caucasian men, aged 50 years, with an apolipoprotein (apo) E3/E3 genotype, who had originally undergone investigations of postprandial lipoprotein metabolism was used for the study. Measurements Total IGF‐I, IGFBP‐1 and IGFBP‐3 were determined in serum by radioimmunoassay (RIA). Free IGF‐I was measured by a commercial two‐site immunoradiometric assay (IRMA). Results In multivariate analyses, fasting serum free IGF‐I correlated inversely with IMT and accounted for 5% of the variation in multiple R 2 . When fasting serum IGFBP‐1 was entered in the models instead of IGF‐I, IGFBP‐1 correlated positively with IMT and accounted for 6% of the variation in IMT. IGFBP‐3 and total IGF‐I were unrelated to IMT. There were no associations between free IGF‐I and cardiovascular risk factors, whereas IGFBP‐1 behaved like a component of the insulin resistance syndrome. Serum free IGF‐I increased and IGFBP‐1 decreased postprandially. Conclusion The data indicate that serum free IGF‐I and IGFBP‐1 are implicated in early atherosclerosis.