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Treatment of acromegaly improves quality of life, measured by AcroQol
Author(s) -
Paisley Angela N.,
Rowles Susannah V.,
Roberts Margaret E.,
Webb Susan M.,
Badia X.,
Prieto L.,
Shalet Stephen M.,
Trainer Peter J.
Publication year - 2007
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2007.02891.x
Subject(s) - acromegaly , medicine , quality of life (healthcare) , sss* , correlation , gastroenterology , endocrinology , hormone , growth hormone , geometry , nursing , mathematics
Summary Background AcroQol is a disease‐generated questionnaire, developed to assess quality of life (QOL) in patients with acromegaly. We have previously demonstrated severely impaired QOL in patients with acromegaly and the value of AcroQol in measuring QOL in a cross‐sectional study compared with the non‐disease‐specific generic tools ‘Psychological general wellbeing schedule’ (PGWBS) and EuroQol (EQ‐5D), and the disease‐specific signs and symptoms score (SSS). Aim, subjects and methods We re‐evaluated these tools in a longitudinal study of 56 of the previously reported patients (33 male, mean age 55 ± 15 years), in order to determine change in QOL over time and the effect of different treatment modalities. Data were analysed using Spearman's correlation tests. Results Baseline median IGF‐I was 354 ng/ml (range 48–899) and at re‐evaluation 217 ng/ml (60–594) ( P < 0·001) [median time interval 608 days (113–1136)]. Analysis of change in IGF‐I levels and AcroQol scores demonstrated a significant negative correlation (i.e. a reduction in IGF‐I being associated with improved overall QOL ( r = –0·36, P = 0·006). Significant negative correlations were also seen in the physical ( r = –0·33, P = 0·01), psychological ( r = –0·37, P = 0·005) and appearance ( r = –0·42, P = 0·001) AcroQol subdomains. No correlations were seen between change in IGF‐I and change in overall PGWBS score or subdomains, SSS or EQ‐5D. Conclusions In summary, of the tools studied we have demonstrated AcroQol to be uniquely capable of detecting changes in QOL associated with treatment‐induced improvement in the main biochemical marker of disease activity in patients with acromegaly. Further studies are required to evaluate the long‐term biological significance of the changes seen in AcroQol.