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The adaptation and relationship of FGF‐23 to changes in mineral metabolism in Graves’ disease
Author(s) -
Park Se Eun,
Cho Mi Ae,
Kim Se Hwa,
Rhee Yumie,
Kang Eun Seok,
Ahn Chul Woo,
Cha Bong Soo,
Lee Eun Jig,
Kim Kyung Rae,
Lee Hyun Chul,
Lim SungKil
Publication year - 2007
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2007.02824.x
Subject(s) - medicine , endocrinology , fibroblast growth factor 23 , bone remodeling , graves' disease , vitamin d and neurology , osteocalcin , bone mineral , n terminal telopeptide , parathyroid hormone , calcium metabolism , euthyroid , calcium , disease , chemistry , hormone , osteoporosis , alkaline phosphatase , biochemistry , enzyme
Summary Objective The aim of this study was to observe the changes in bone and mineral metabolism and to confirm the regulation of fibroblast growth factor‐23 (FGF‐23) in untreated Graves’ disease. Patients and measurements The study comprised 39 patients, with or without Graves’ disease. The Graves’ disease group was made up of 21 newly diagnosed patients, enrolled before starting treatment. Their disease was determined by biochemical and radiological means. The control group was composed of 18 people who were proven to be euthyroid without any diseases affecting bone and mineral metabolism. FGF‐23, calcium, phosphate, PTH, 25‐hydroxyvitamin D [25(OH)D] and 1,25‐dihydroxyvitamin D [1,25(OH) 2 D] levels and bone turnover markers were compared between these groups. Results Serum calcium and phosphate, plasma FGF‐23 and free T4 were significantly higher in the Graves’ disease group than in the healthy control group ( P < 0·05). The bone turnover markers serum osteocalcin and C‐terminal cross‐linked telopeptide of type 1 collagen (s‐CTx) were also significantly elevated in the Graves’ disease group, and had a positive correlation with free T4 levels. However, there was no significant decrease in PTH and 1,25(OH) 2 D in the Graves’ disease group. Plasma levels of FGF‐23 exhibited a positive correlation with serum phosphate levels and with free T4 levels ( P < 0·05). Conclusions These findings suggest that FGF‐23 is physiologically related to serum phosphate homeostasis, as indicated indirectly by the changes in bone and mineral metabolism, in untreated Graves’ disease.