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Independent association between insulin‐like growth factor‐I and dehydroepiandrosterone sulphate in women in middle adulthood
Author(s) -
Kasayama Soji,
Morita Shinya,
Otsuki Michio,
Asanuma Nobuyuki,
Saito Hiroshi,
Mukai Mikio,
Koga Masafumi
Publication year - 2007
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2007.02815.x
Subject(s) - medicine , endocrinology , dehydroepiandrosterone sulfate , dehydroepiandrosterone , diabetes mellitus , insulin like growth factor , hormone , insulin , disease , growth factor , androgen , receptor
Summary Objective The age‐related decrease in circulating dehydroepiandrosterone sulphate (DHEAS) and insulin‐like growth factor (IGF)‐I levels is suggested to be involved in various age‐related changes. As both hormones are regulated differently, by ACTH and GH, respectively, reasons for the almost parallel changes of their circulating levels during ageing remain unknown. The objectives of this study were to verify variables that influence serum IGF‐I as well as DHEAS levels in subjects in middle adulthood. Subjects and methods We determined serum DHEAS and IGF‐I levels in 362 Japanese subjects aged 30–65 years (225 men and 137 women) undergoing health examinations, who had no hepatic disease, renal disease, malignant disease, diabetes mellitus, or asthma. Variables influencing DHEAS and IGF‐I were analysed. Results DHEAS as well as IGF‐I levels were higher in men than in women. DHEAS was positively associated with IGF‐I and negatively with age, in both men and women. By multivariate regression analysis, age was negatively associated with DHEAS in both men and women. IGF‐I was found to be independently associated with DHEAS in women. Age was the only negative independent factor for IGF‐I in both men and women, while DHEAS was the only positive independent factor in women. Conclusions The present study demonstrates that DHEAS and IGF‐I levels are associated with each other, independent of age, in women in middle adulthood.