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Do serum leptin levels have a role in the prediction of pregnancy outcome in case of threatened miscarriage?
Author(s) -
Tommaselli Giovanni A.,
Di Spiezio Sardo Attilio,
Di Carlo Costantino,
Bifulco Giuseppe,
Cerrota Giuseppe,
Cirillo Domenico,
Greco Elena,
Nappi Carmine
Publication year - 2006
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2006.02665.x
Subject(s) - miscarriage , leptin , pregnancy , medicine , radioimmunoassay , threatened abortion , obstetrics , abortion , threatened species , endocrinology , biology , obesity , ecology , genetics , habitat
Summary Objective To determine whether maternal serum leptin levels can predict pregnancy outcome in cases of threatened miscarriage. Design Observational study. Patients Fifty‐seven women with normal pregnancy (group A), 19 women with threatened miscarriage who delivered at term (group B), 22 women with threatened miscarriage with subsequent miscarriage (group C) and 27 women with delayed miscarriage (group D). Measurements Maternal serum leptin was determined using a commercial radioimmunoassay (RIA) kit. Results Serum leptin levels were not significantly different among groups A, B and C [median (range) 17·6 (10·1–26·5), 18·2 (12·5–25·6) and 17·3 (11·2–27·6) µg/l, respectively]. Women in group D showed significantly lower serum leptin levels in comparison with other groups [14 (6·7–21·3) µg/l; P < 0·05]. Conclusions Serum leptin levels in the first trimester of pregnancy may not be the primary indicator of miscarriage in cases of threatened abortion.