Premium
Effects of the IGF‐I/IGFBP‐3 complex on GH and ghrelin nocturnal concentrations in low birth weight children
Author(s) -
Iñiguez German,
Salazar Teresa,
Roman Rossana,
Avila Alejandra,
Gunn Ronald D.,
Cassorla Fernando
Publication year - 2006
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2006.02650.x
Subject(s) - ghrelin , medicine , endocrinology , basal (medicine) , birth weight , area under the curve , nocturnal , pregnancy , hormone , biology , diabetes mellitus , genetics
Summary Objective There is limited information regarding the effects of IGF‐I and/or IGFBP‐3 on circulating ghrelin concentrations. To determine the effects of IGF‐I on GH and ghrelin concentrations, we examined the GH and ghrelin nocturnal profiles before and after the administration of the IGF‐I/–IGFBP‐3 complex (Iplex™) to low birth weight children. Design The children were studied on two separate occasions, the first under basal conditions, and the second time after the sc administration of 1 mg/kg of Iplex™ at 2100 h. Blood samples for determination of GH and ghrelin were obtained every 20 min between 2300 h and 0700 h, while the children were sleeping. In each patient, we calculated the mean GH and ghrelin area under the curve (GH AUC and GHR AUC), both under basal conditions and after the administration of the IGF‐I/IGFBP‐3 complex. Setting The study was performed at a University Research Centre located at a General Hospital in Santiago, Chile. Patients Twenty prepubertal children (11 boys and 9 girls), born after a full‐term pregnancy with a birth weight below 2·8 kg were studied at a mean ± SEM age of 7·3 ± 0·5 years (range 4–11 years). Their mean height was −1·8 ± 0·3 standard deviation score (SDS) and their mean BMI was 0·1 ± 0·2 SDS at the time of the study. Main outcome and results Mean nocturnal GH AUC exhibited a significant decrease (2903 ± 185 vs 1860 ± 122 ng/ml min, P < 0·01), whereas mean GHR AUC showed a significant increase after administration of the IGF‐I/IGFBP‐3 complex (68 ± 16 vs 288 ± 36 ng/ml min, P < 0·01). Conclusions These findings indicate that the IGF‐I/IGFBP‐3 complex appears to have opposite effects on circulating GH and ghrelin concentrations in low birth weight children, suggesting that, in addition to its known negative feed‐back effect on GH, IGF‐I and/or IGFBP‐3 may have a positive feed‐back effect on ghrelin.