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The significance of thyroid blood flow at the inferior thyroid artery as a predictor for early Graves’ disease relapse
Author(s) -
Ueda Misako,
Inaba Masaaki,
Kumeda Yasuro,
Nagasaki Toshiki,
Hiura Yoshikazu,
Tahara Hideki,
Onoda Naoyoshi,
Ishikawa Tetsuro,
Nishizawa Yoshiki
Publication year - 2005
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2005.02397.x
Subject(s) - euthyroid , medicine , trab , thyroid , endocrinology , graves' disease , thyroid disease , inferior thyroid artery , triiodothyronine , cardiology , recurrent laryngeal nerve
Summary Objective We investigated the clinical usefulness of thyroid blood‐flow measurement in predicting relapse of Graves’ disease (GD) in comparison with known risk factors for GD relapse. Measurement Thyroid blood flow was measured in pulsed Doppler mode at the inferior thyroid artery (ITA), and the peak systolic velocity (PSV) calculated. Patients ITA‐PSV was measured in euthyroid GD patients ( n = 79) immediately before withdrawal of anti‐thyroid drug (ATD) and in healthy subjects ( n = 17). Results In the 79 euthyroid GD patients, the values of free triiodothyronine (FT3), TSH receptor autoantibody (TRAb), ITA‐PSV and thyroid volume were significantly higher in the relapse group ( n = 40) than in the nonrelapse group ( n = 39) and the Youden index of ITA‐PSV was significantly higher than that of FT3, TSH, TRAb and vascular endothelial growth factor (VEGF). Conclusion ITA‐PSV may assist in the prediction of early GD relapse after ATD withdrawal.