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Metformin administration and laparoscopic ovarian drilling improve ovarian response to clomiphene citrate (CC) in oligo‐anovulatory CC‐resistant women with polycystic ovary syndrome
Author(s) -
Palomba Stefano,
Orio Francesco,
Falbo Angela,
Russo Tiziana,
Caterina Grande,
Manguso Francesco,
Tolino Achille,
Colao Annamaria,
Zullo Fulvio
Publication year - 2005
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2005.02392.x
Subject(s) - metformin , polycystic ovary , medicine , endocrinology , ovary , insulin resistance , insulin
Summary Objective To compare the efficacy of clomiphene citrate (CC) administration for ovulation induction in CC‐resistant oligo‐ovulatory women with polycystic ovary syndrome (PCOS) after metformin treatment or laparoscopic ovarian drilling (LOD). Design Prospective controlled study. Patients Twenty‐eight overweight oligo‐amenorrhoeic women with PCOS who were still anovulatory after metformin administration (group A, n = 8) or LOD (group B, n = 20). Methods Treatment with CC 150 mg/day for 5 days from the third to the seventh day of a progesterone‐induced uterine bleeding for 6 months. Measurements The ovulation, pregnancy, abortion and live‐birth rates were evaluated in each group. Results The subjects of groups A and B were studied for a total of 36 and 74 cycles, respectively. At the end of the study, no differences in ovulation [11/36 (30·6%) vs. 23/74 (31·1%); P = 0·96], pregnancy [6/36 (16·7%) vs. 12/74 (16·2%); P = 0·95], abortion [2/6 (33·3%) vs. 5/12 (41·7%); P = 1·00] and the live‐birth [4/6 (66·7%) vs. 7/12 (58·3%); P = 1·00] rates were observed between groups A and B. Conclusion Metformin administration as well as LOD improves the effectiveness of CC for ovulation induction in overweight infertile CC‐resistant women with PCOS.